Rafael de Cabo of the National Institute on Ageing in Baltimore , Maryland , US, said calorie restriction in laboratory animals has shown to increase their lifespan. However, the human implications of the study were unclear, the researchers said in the journal Nature Communications. Metformin is a widely prescribed treatment for type-2 diabetes, which occurs mainly in people above the age of 40. It is also used to treat metabolic syndrome, a combination of diabetes, high blood pressure and obesity. Earlier work has shown that metformin can extend the lifespan of simple organisms like worms, but studies in flies and mammals have given conflicting evidence. The scientists gave one of two different doses of metformin to middle-aged male mice and found that lower doses increased lifespan by about five per cent, and also delayed the onset of age-associated diseases.
For the original version including any supplementary images or video, visit http://timesofindia.indiatimes.com/life-style/health-fitness/health/Diabetes-pill-may-have-anti-ageing-effects/articleshow/21619351.cms
What is gestational diabetes?
(The placenta is the organ connecting the baby by the umbilical cord to the uterus and sends nutrients from mother to child.) As the placenta becomes larger throughout pregnancy, it creates more hormones, which, in turn, increases the insulin resistance, the Cleveland Clinic said. The mother’s pancreas is typically able to make three times the normal amount of insulin to beat this resistance, according to the Cleveland Clinic. If the pancreas can’t produce the required amount of insulin, however, sugar levels will rise, and the woman will have gestational diabetes. You may be at risk for gestational diabetes if you are overweight before becoming pregnant, have a family history of diabetes, are older than 25, have previously giving birth to a baby over 9 pounds, previously gave birth to a stillborn baby, have had gestational diabetes with a previous pregnancy or have been diagnosed with pre-diabetes, the Cleveland Clinic said. Women typically find out whether they have gestational diabetes between the 24th and 28th weeks of pregnancy, according to the Cleveland Clinic. That’s when insulin resistance usually begins.
For the original version including any supplementary images or video, visit http://www.cnn.com/2013/08/01/health/gestational-diabetes
Structure of a Potential Diabetes Drug Target
An international team, led by Drs. Fai Yiu Siu and Raymond C. Stevens of Scripps Research Institute, set out to determine the structure of the glucagon receptor. Their study was funded in part by NIHs National Institute of General Medical Sciences (NIGMS) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Results appeared in the July 25, 2013, issue of Nature along with research from a British group that reported the structure of another class B receptor, corticotropin-releasing factor receptor type 1. The scientists, who have extensive experience working with receptors, used a fusion protein to painstakingly create crystals of the glucagon receptor so that the structure could be determined by X-ray crystallography. In addition, they altered more than 100 different amino acids in the receptor protein to better understand what parts of the receptor help bind the hormone.
For the original version including any supplementary images or video, visit http://www.nih.gov/researchmatters/august2013/08052013structure.htm
Diabetes drug may increase life span
Caloric restriction means eating fewer calories than are burned every day, and has been shown in animal studies to increase life span. But in the new study, mice fed metformin were not put on a restrictive diet in fact, they ate more calories than those not fed metformin. The study suggests a possible way to reap the benefits of caloric restriction without food deprivation. However, it’s too soon to know whether the results apply to humans. For one, the mice that lived longer had blood levels of metformin that were 10 times higher than those seen in humans taking the drug to treat diabetes, the researchers said. And mice put on an even higher dose of metformin actually had a decreased life span, because the drug was toxic (it caused kidney failure). Mice were also fed a controlled diet for their whole life, which is not true of people, said study researcher Rafael de Cabo, a senior investigator at the National Institute on Aging.
For the original version including any supplementary images or video, visit http://www.foxnews.com/health/2013/07/31/diabetes-drug-may-increase-life-span/
Diabetes glucose test strips Nova Max recalled
Food and Drug Administration, has recalled 21 lots of glucose test strips manufactured between December 2011 and April 2013. These strips, which are also sold in the Nova Max Plus Blood Glucose Meter Kits, may report back false, abnormally high blood glucose readings. The FDA warns that these false readings may result in insulin dosing errors. Visit our diabetes guide to learn more about how to handle the disease. If you currently use Nova Max Glucose Test Strips, or have the Nova Max Plus Blood Glucose Monitoring system, call Nova Diabetes Care customer service at 1-800-681-7390 to see if your strips are from a defective lot. If your strips are indeed defective, immediately stop using them and continue to monitor your blood sugar using either a different monitoring system or unaffected Nova Max test strips.
For the original version including any supplementary images or video, visit http://consumerreports.org/cro/news/2013/08/diabetes-glucose-test-strips-nova-max-recalled/index.htm